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The Great Age Reboot – Global Macro Update

This week, I spoke with Dr. Michael Roizen, Chief Wellness Officer at the Cleveland Clinic, and author of “The Great Age Reboot: Cracking the Longevity Code for a Younger Tomorrow.” We talked about how current science and technology will revolutionize our ability to live longer and live better. We also discussed the economic and policy implications that come with longevity as a disruptor.

In this edition, you’ll hear Dr. Roizen and me discuss:

- Why people living to 100, 120, or even 130 years old will become increasingly common—and how life past 100 may not look like what you expect…
- How induced tissue regeneration could potentially eliminate obesity…
- Two breakthrough anti-aging technologies that have moved from clinical trials into human testing…
- What actions you should take now to prepare for the coming breakthroughs in life extension technology…
- Why 90 will become the new 40 within the next 10 years…

Dr. Michael Roizen’s new book, “The Great Age Reboot: Cracking the Longevity Code for a Younger Tomorrow,” is available for purchase here:

Like what you’ve seen in this interview? Sign up for “Global Macro Update” by clicking here: It’s free, and you can elect to stop receiving it at any time.


Video Time Stamps

00:00 - Introduction
01:08 - The Great Age Reboot
02:28 - Why we’re on the cusp of longer life
02:41 - The 14 areas where there has been exponential progress in understanding the mechanisms of aging
03:02 - The upward trajectory of life expectancy
04:20 - The coming 30-year shift of quality life expectancy
04:32 - Why 90 will become the new 40
05:06 - What “rebooting” our bodies will mean
05:27 - The 14 key research areas underpinning life extension
05:45 - The two key technologies moving from clinical trials into human testing
06:36 - The current successes of gene editing
07:55 - Why life extension technology is surprisingly cost-effective
08:44 - Senolytics and therapeutic plasma exchange
09:23 - The youngblood hypothesis
10:02 - Improving cognitive function
10:24 - Why this technology affects people who are alive now
11:43 - The exponential nature of life-extension technology improvement
12:47 - How induced tissue regeneration is transforming white fat cells into pluripotent stem cells and turning them into brown fat
13:42 - How we could eliminate obesity
15:03 - Why it’s not just slowing aging but “rebooting” your body
15:35 - Why life extension technology is coming within 10 years
16:31 - What you should do now to prepare
17:31 - The next phase will be organ by organ
19:48 - The bizarre family structures that will result from life extension
20:48 - Why males will be able to regain testicular function at advanced ages
21:04 - The current studies occurring on ovarian regeneration
21:44 - The financial challenges of life extension technology
22:24 - The unexpected but powerful effects of even a small monthly retirement account
23:47 - How public policy must change to meet the new realities of lifespans
24:30 - Why life extension could save Social Security and social safety nets
26:17 - What medical specialties will thrive in the age of life extension and which will wither
26:41 - The effects of hyperbaric oxygen in elastin and collagen in skin and other tissues
28:51 - The coming boom in GDP and real estate
29:09 - Where to get the new book and how to pre-order it
30:38 - How bioreactor plants, gene editing, and yeast could produce enough food to feed the entire world twice over
32:38 - Outro

Want a transcript of this video? Click here to access it:
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John Mauldin
Each week, investors and financial professionals around the globe turn to John Mauldin to better understand Wall Street, global markets, and the drivers of the world economy. And for good reason. John is a noted financial expert, a New York Times best-selling author, a pioneering online commentator, and the publisher of one of the first publications to provide investors with free, unbiased information and guidance—Thoughts from the Frontline—one of the most widely read investment newsletters in the world.
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